Cramped toes/loose heels (latter led to the fabric/padding getting worn away at the heel, which also ripped my socks open).
Tended to skate around over Time cleats; thought I just needed to get used to them, but it's always been more of an issue clipping in than with SPD sandals or my old Northwaves.
Sole slopes inwards to a narrow footprint, so your ankle can roll over quite easily while walking.
Ratchet mechanism seizes up if it gets clogged with mud/heather.
Because of the cramped toes (I don't have wide feet) I had to remove the insole, and the hard surface underneath gets uncomfortable on long days in the saddle.
Summary - race shoe; in fairness that's what they're designed for, rather than the big days I do, but I had no choice, they were the only shoes available at the time I needed them. I've just got a set of Shimanos that fit much better out of the box.